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However, UBXD8, a protein in the ER-associated degradation (ERAD) pathway, can bind PNPLA2, preventing the interaction with ABHD5, thereby segregating PNPLA2 to valosin-containing protein (VCP)/p97 segragrase that promotes extraction and subsequent Ub-dependent degradation (132) (Figure 1)

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and people with an MTHFR genetic polymorphism (or mutation) whose cells are less efficient at converting folate into its active form